17 trending supplement DTC brands to watch this year

The direct-to-consumer (DTC) supplement industry has experienced remarkable growth as consumers increasingly seek personalized wellness solutions from brands they trust. 

Today’s health-conscious customers demand transparency, quality ingredients, and direct relationships with supplement companies. From innovative formulations to science-backed solutions, trending supplement DTC brands are reshaping how we approach health and wellness. 

Whether you’re looking to launch your own supplement brand or simply curious about the industry leaders, these 17 trending supplement DTC brands showcase what’s possible when you combine quality products with customer-centric approaches.

What sets DTC supplement brands apart

The rise of trending supplement DTC brands in the supplement industry is transforming how people approach wellness. By cutting out the middleman, these brands offer high-quality, science-backed products directly to consumers. Here’s what makes them stand out:

• Transparency & clean ingredients – Consumers want to know what’s in their supplements. Leading DTC brands prioritize transparency, using high-quality, ethically sourced ingredients while avoiding artificial additives and fillers.
• Personalized health solutions – Unlike traditional one-size-fits-all supplements, many DTC brands offer personalized products based on online quizzes or expert recommendations, making wellness routines more effective.
• Customer education & trust – Top brands go beyond selling – they educate. Through blogs, social media, and expert-backed content, they help consumers understand ingredients, benefits, and proper usage, fostering trust.
• Digital marketing & convenience – With direct online sales, influencer partnerships, and subscription models, DTC brands create stronger customer relationships while making supplement routines seamless and cost-effective.

Best DTC supplement brands in 2025

Leading direct to consumer brands are reshaping how we approach health and wellness. Here’s a list of best DTC brands that are making waves in the supplement industry:

Ritual 

Pioneering transparency in the supplement space, Ritual has made a name for itself with traceable ingredients and clear messaging. Their range spans from prenatal to postnatal vitamins, each designed with essential nutrients for specific life stages. 

What sets them apart is their visible supply chain – customers can trace every ingredient back to its source. Additionally, their subscription model ensures customers never run out of their daily essentials.

HUM Nutrition

HUM Nutrition is a leader in beauty and wellness supplements, offering targeted solutions for skin, hair, digestion, and stress support. Their formulations are backed by clinical research, and the brand’s colorful, playful approach to vitamins makes wellness feel accessible and fun.

Seed

Seed stands out in the gut health market with its synbiotic formula, a powerful blend of prebiotics and probiotics. Their innovative two-in-one capsule protects live cultures through digestion, increasing effectiveness. With a science-first approach and a commitment to sustainability, Seed has built a loyal following among health-conscious consumers.

Athletic Greens (AG1)

Athletic Greens, now known as AG1, is one of the most recognizable daily greens powders on the market. Packed with 75 vitamins, minerals, and probiotics, AG1 is designed to replace multiple supplements in one scoop. With its strong influencer network and dedicated subscription model, AG1 remains a favorite among active lifestyle enthusiasts.

OLLY

OLLY combines wellness with fun, offering gummy vitamins that support sleep, stress relief, beauty, and immunity. Their vibrant branding and approachable formulas attract a wide audience, including those new to supplements. Available both online and in retail stores, OLLY continues to dominate the DTC and mass-market supplement space.

Moon Juice

Moon Juice blends adaptogens, nootropics, and botanicals into wellness powders that promote energy, mental clarity, and relaxation. Their products cater to consumers looking for holistic, plant-based solutions and have gained a cult following in the wellness community.

Persona Nutrition

Persona Nutrition offers personalized supplement packs designed around individual health needs. Customers complete a quick health assessment, and the brand curates a customized daily vitamin regimen. With free nutritionist consultations and a flexible subscription model, Persona provides an expert-driven, tailored approach to wellness.

Gainful

Gainful brings customization to sports nutrition, offering personalized protein powders that match dietary preferences and fitness goals. Customers can select ingredients and flavors, ensuring they get the exact blend they need. With an interactive quiz and a direct-to-door subscription model, Gainful makes personalized fitness supplementation easy.

Needed

Needed is redefining prenatal and postnatal nutrition with high-quality, doctor-approved supplements designed for growing families. Their science-backed formulations support fertility, pregnancy, and postpartum health, filling gaps left by traditional prenatal vitamins. By partnering with health professionals and midwives, Needed has become a trusted name in family-focused wellness.

Truvani

Truvani takes a clean-label approach to supplements, offering organic protein powders and immunity-boosting products made without artificial additives. Co-founded by wellness advocate Vani Hari (aka “The Food Babe”), Truvani is built on transparency and simple, natural ingredients. 

Their strong commitment to organic and non-GMO certification resonates with health-conscious consumers looking for real-food-based supplements.

Four Sigmatic

Four Sigmatic combines functional mushrooms and adaptogens to create superfood powders, coffee blends, and elixirs that support immune health, cognitive function, and relaxation. The brand’s innovative formulations bring science-backed mushroom benefits into daily wellness routines, making holistic health more accessible.

Ketone-IQ®

Ketone-IQ® focuses on performance-driven nutrition, offering keto-friendly products and nootropic supplements designed for mental clarity, energy, and endurance. Their exogenous ketones and brain-boosting formulations cater to biohackers, athletes, and those optimizing their metabolic health. 

Equi London

Equi London is a women’s health-focused supplement brand, offering hormone-balancing formulas, energy boosters, and skin-supporting nutrients. Their plant-based, high-potency formulations are designed for modern women looking for holistic, science-backed solutions. With a strong emphasis on nutritional synergy and bioavailability, Equi London has gained a loyal following in the wellness space.

Peak Performance

Peak Performance delivers organic, non-GMO supplements, including greens powders, immune support formulas, and energy boosters. Their commitment to third-party testing and clean, sustainable sourcing has made them a favorite among health-conscious consumers. With a strong focus on quality and transparency, Peak Performance continues to build trust in the DTC wellness market.

1st Phorm

1st Phorm is a fitness-focused supplement brand that offers high-quality protein powders, energy drinks, and pre-workout formulas. Known for its premium ingredients and effective formulations, 1st Phorm has built a loyal customer base among athletes and fitness enthusiasts. Their direct-to-consumer model and strong community engagement set them apart in the competitive sports nutrition space.

Clean Simple Eats

Clean Simple Eats is changing the protein supplement game with macro-friendly protein powders, high-protein snacks, and wellness products. Their simple, clean ingredient lists and delicious flavors have earned them a dedicated following. With a focus on healthy, balanced nutrition, Clean Simple Eats has become a go-to brand for fitness lovers and health-conscious consumers.

Beam

Beam specializes in CBD-infused wellness products, including powders for sleep, relaxation, and recovery. The brand’s plant-based, science-backed approach appeals to those seeking natural stress relief and performance recovery. With a focus on transparency, quality, and innovation, Beam is making waves in the growing CBD and wellness supplement market.

Final thoughts 

The supplement industry is evolving, and trending supplement DTC brands are leading the way with transparency, personalization, and innovative wellness solutions. These brands prioritize high-quality ingredients, expert-backed formulations, and direct customer engagement, making it easier than ever to find supplements that fit individual health needs. Whether it’s probiotics, protein powders, or daily multivitamins, DTC brands are redefining how people approach their health. 

As demand for science-backed, direct-to-consumer solutions grows, these brands will continue to redefine supplementation, helping consumers take control of their health with smarter, more personalized options.

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